Tinnitus is a frequent disorder and its treatment is elusive. Many different treatment options have been investigated but most trials provided inconclusive results with some patients responding and many others without any benefit. These results suggest that there exist different forms of tinnitus which differ in their pathophysiology and their response to specific treatments. A challenge for tinnitus treatment and tinnitus research is therefore the identification of the most promising therapy for a specific patient. One approach to address this challenge is the systematic assessment of tinnitus patients in many clinical centers with standardized instruments (e.g., psychoacoustic measures, questionnaires). For this purpose the Tinnitus Research Initiative database has been created, which is further developed and enlarged in the current COST Action TINNET.
The database was developed by the Tinnitus Research Initiative (TRI) and the Department for Psychiatry and Psychotherapy of the University of Regensburg and the Institute for Databases and Information Systems (DBIS) at the University of Ulm.
Department of Psychiatry and Psychotherapy
Department of Psychiatry and Psychotherapy
Department of Psychiatry and Psychotherapy
Department of Psychiatry and Psychotherapy
Department of Psychiatry and Psychotherapy
Center for Clinical Studies
Department of Psychiatry and Psychotherapy
Department of Psychiatry and Psychotherapy
Institute of Databases and Information Systems
Institute of Databases and Information Systems
Institute of Databases and Information Systems
Developer
Developer
Developer
Developer
Institute of Databases and Information Systems
Institute of Databases and Information Systems
Designer
Designer
Designer
Developer
Developer
Developer
Department of Technical and Business Information Systems
Department of Technical and Business Information Systems
Department of Technical and Business Information Systems
Department of Technical and Business Information Systems
"Report on the Big Data Conference in ENT Clinical Research", Paris IFOS Conference, http://www.lorenzinifoundation.org/big-data-conference-ent-clinical-research, 2017, [Online; accessed 08-January-2018]
Langguth B, Landgrebe M, Schlee W, et al. Different Patterns of Hearing Loss among Tinnitus Patients: A Latent Class Analysis of a Large Sample. Frontiers in Neurology. 2017;8:46. doi:10.3389/fneur.2017.00046.
Vielsmeier, Veronika and Kreuzer, Peter and Haubner, Frank and Steffens, Thomas and Semmler, Philipp and Kleinjung, Tobias and Schlee, Winfried and Langguth, Berthold and Schecklmann, Martin (2016). Speech comprehension difficulties in chronic tinnitus and its relation to hyperacusis. In: Frontiers in Aging Neuroscience. Volume 8, Pages 293. DOI 10.3389/fnagi.2016.00293.
Insomnia in patients with chronic tinnitus: Cognitive and emotional distress as moderator variables. Crönlein T, Langguth B, Pregler M, Kreuzer PM, Wetter TC, Schecklmann M. J Psychosom Res. 2016 Apr;83:65-8. doi: 10.1016/j.jpsychores.2016.03.001.
Tinnitus and Headache. Langguth B, Hund V, Busch V, Jürgens TP, Lainez JM, Landgrebe M, Schecklmann M. Biomed Res Int. 2015;2015:797416. doi: 10.1155/2015/797416.
Psychophysiological Associations between Chronic Tinnitus and Sleep: A Cross Validation of Tinnitus and Insomnia Questionnaires. Schecklmann M, Pregler M, Kreuzer PM, Poeppl TB, Lehner A, Crönlein T, Wetter TC, Frank E, Landgrebe M, Langguth B. Biomed Res Int. 2015;2015:461090. doi: 10.1155/2015/461090.
The Relevance of the High Frequency Audiometry in Tinnitus Patients with Normal Hearing in Conventional Pure-Tone Audiometry. Vielsmeier V, Lehner A, Strutz J, Steffens T, Kreuzer PM, Schecklmann M, Landgrebe M, Langguth B, Kleinjung T. Biomed Res Int. 2015;2015:302515. doi: 10.1155/2015/302515.
Validation of Screening Questions for Hyperacusis in Chronic Tinnitus. Schecklmann M, Lehner A, Schlee W, Vielsmeier V, Landgrebe M, Langguth B. Biomed Res Int. 2015;2015:191479. doi: 10.1155/2015/191479.
Schecklmann, M., Landgrebe, M., Langguth, B., & TRI Database Study Group. (2014). Phenotypic characteristics of hyperacusis in tinnitus. PLoS One, 9(1), e86944.
Zeman, F., Koller, M., Langguth, B., & Landgrebe, M. (2014). Which tinnitus-related aspects are relevant for quality of life and depression: results from a large international multicentre sample. Health and quality of life outcomes, 12(1), 1.
Milerová, J., Anders, M., Dvo?ák, T., Sand, P. G., Königer, S., & Langguth, B. (2013). The influence of psychological factors on tinnitus severity. General hospital psychiatry, 35(4), 412-416.
Landgrebe, M., Azevedo, A., Baguley, D., Bauer, C., Cacace, A., Coelho, C., ... & van de Heyning, P. (2012). Methodological aspects of clinical trials in tinnitus: a proposal for an international standard. Journal of psychosomatic research, 73(2), 112-121.
Schecklmann, M., Vielsmeier, V., Steffens, T., Landgrebe, M., Langguth, B., & Kleinjung, T. (2012). Relationship between audiometric slope and tinnitus pitch in tinnitus patients: insights into the mechanisms of tinnitus generation. PLoS One, 7(4), e34878.
Adamchic, I., Tass, P. A., Langguth, B., Hauptmann, C., Koller, M., Schecklmann, M., ... & Landgrebe, M. (2012). Linking the Tinnitus Questionnaire and the subjective Clinical Global Impression: Which differences are clinically important?. Health and quality of life outcomes, 10(1), 1.
Zeman, F., Koller, M., Schecklmann, M., Langguth, B., & Landgrebe, M. (2012). Tinnitus assessment by means of standardized self-report questionnaires: psychometric properties of the Tinnitus Questionnaire (TQ), the Tinnitus Handicap Inventory (THI), and their short versions in an international and multi-lingual sample. Health and quality of life outcomes, 10(1), 1.
Kreuzer, P. M., Landgrebe, M., Schecklmann, M., Staudinger, S., & Langguth, B. (2012). Trauma-associated tinnitus: audiological, demographic and clinical characteristics. PLoS One, 7(9), e45599.
Coelho, C., Figueiredo, R., Frank, E., Burger, J., Schecklmann, M., Landgrebe, M., ... & Elgoyhen, A. B. (2012). Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study. Audiology and Neurotology, 17(3), 179-188.
Schecklmann, M., Lehner, A., Poeppl, T. B., Kreuzer, P. M., Hajak, G., Landgrebe, M., & Langguth, B. (2012). Cluster analysis for identifying sub-types of tinnitus: a positron emission tomography and voxel-based morphometry study. Brain research, 1485, 3-9.
Zeman, F., Koller, M., Figueiredo, R., Aazevedo, A., Rates, M., Coelho, C., ... & Landgrebe, M. (2011). Tinnitus Handicap Inventory for Evaluating Treatment Effects Which Changes Are Clinically Relevant?. Otolaryngology--Head and Neck Surgery, 145(2), 282-287.
Langguth, B., Kleinjung, T., & Landgrebe, M. (2011). Tinnitus: the complexity of standardization. Evaluation & the health professions, 0163278710394337.
Langguth, B., Kleinjung, T., & Landgrebe, M. (2011). Severe tinnitus and depressive symptoms: a complex interaction. Otolaryngology--Head and Neck Surgery, 145(3), 519-519.
Landgrebe, M., Zeman, F., Koller, M., Eberl, Y., Mohr, M., Reiter, J., ... & Langguth, B. (2010). The Tinnitus Research Initiative (TRI) database: a new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome. BMC medical informatics and decision making, 10(1), 1.
Langguth, B., Goodey, R., Azevedo, A., Bjorne, A., Cacace, A., Crocetti, A., ... & Flor, H. (2007). Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006. Progress in brain research, 166, 525-536.
Erdem, Buket (2016) Designkonzept einer mobilen und spielorientierten Anwendung zur Unterstützung Tinnitus-geschädigter Patienten. Bachelor thesis, Ulm University. | ![]() |
Baltakiranoglu, Burak (2015) Konzeption und Realisierung eines Patientenmoduls für eine multinationale und interdisziplinäre Datenbank. Master thesis, Ulm University. | ![]() |
Blome, Jan-Dominik (2015) Implementation and evaluation of a mobile Android application for auditory stimulation of chronic tinnitus patients. Master thesis, Institute of Databases and Information Systems. | ![]() |
Hagenlocher, Robin (2015) Designkonzept für eine Webanwendung zum Zugriff auf eine interdisziplinäre und multinationale Datenbank zur Erfassung Tinnitus-geschädigter Patienten. Master thesis, Ulm University. | ![]() |
Stenske, Irina (2015) Entwicklung eines Design-Konzepts für eine multinationale Forschungsdatenbank zur Speicherung von longitudinalen Patientendaten. Bachelor thesis, Ulm University. | ![]() |
Aras, Aliyar (2014) Design und Konzeption einer mobilen Anwendung zur Unterstützung tinnitusgeschädigter Patienten. Bachelor thesis, University of Ulm. | ![]() |
Herrmann, Jochen (2014) Konzeption und technische Realisierung eines mobilen Frameworks zur Unterstützung tinnitusgeschädigter Patienten. Diploma thesis, University of Ulm. | ![]() |
Lindinger, Michael (2014) Konzeption und Implementierung einer mobilen Anwendung zur Unterstützung von Tinnitus-Patienten. Master thesis, University of Ulm. | ![]() |
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93053 Regensburg
Susanne.Staudinger[at]medbo.de